Posts tagged "psilocybin"
Moksha Medicine: Powerful Excerpts from Huxley's "Island"

Moksha Medicine: Powerful Excerpts from Huxley’s “Island”

One of my favorite books is Island by Aldous Huxley, a book often prized by psychonauts and others who enjoy looking at society from the outside in. In Island, Huxley lays out the structure for an ideal society while making piercing criticisms of modern Western culture. As the title indicates, Huxley’s utopia is set on a small island, far removed from modern technology and divisive global politics. Some have criticized the book’s characterization and plot, but in Island these are secondary. This book’s main strength is in elaborating a great thinker’s vision of a truly civilized society. I want to share a couple excerpts...
Shrooms for Five: My First Psychedelic Experience

Shrooms for Five: My First Psychedelic Experience

It is a wet February night, and we are gathered at Lee and Dan’s suburban apartment. There are five of us — our hosts, plus Alex, Jason, and me. We have a larger group of friends, but the rest of the crew is not into “serious” drugs. The five of us jokingly call ourselves the “Psychonautic Subcommittee” ever since we tried MDMA for the first time together last fall. Tonight, it’s time to explore a new psychedelic frontier. We each grind an eighth of an ounce of dried mushrooms, mix it with orange juice, and gulp it down....
A Treatise on Psychedelics Part 2/3: The Mystical Experience

A Treatise on Psychedelics Part 2/3: The Mystical Experience

This guest post by Martijn Schirp continues from Part 1, discussing the Interdisciplinary Conference on Psychedelic Research that he attended. It was originally published on higHExistence.com. If we recognize the plant as an autonomous power which enters in order to put roots and flowers in us, then we distance ourselves by several degrees from the skewed perspective which imagines that spirit (Geist) is the monopoly of human beings and doesn’t exist outside of them. A new world-picture has to follow the planetary leveling; that is the task which the next century will take up. –Ernst Jünger, The Plant as Autonomous Power. Where are the...
Low dose psychedelics increase neurogenesis, help mice unlearn fear

Low dose psychedelics increase neurogenesis, help mice unlearn fear

A new study of mice published in Experimental Brain Research shows that low doses (but not high doses) of psychedelics increase the rate of neuron creation in the hippocampus, and help the mice to rapidly unlearn conditioned fear responses. From the abstract (paragraph breaks added for readability): Drugs that modulate serotonin (5-HT) synaptic concentrations impact neurogenesis and hippocampal (HPC)-dependent learning. The primary objective is to determine the extent to which psilocybin (PSOP) modulates neurogenesis and thereby affects acquisition and extinction of HPC-dependent trace fear conditioning. PSOP, the 5-HT2A agonist 25I-NBMeO and the 5-HT2A/Cantagonist ketanserin were administered via an acute intraperitoneal injection...
How Psilocybin Works: Addition by Subtraction

How Psilocybin Works: Addition by Subtraction

Psychedelic Frontier gladly welcomes our first guest, Zizo! A big thanks to Zizo for today’s post about some surprising psilocybin research results. Psilocybin is the inactive precursor of psilocin, the chemical primarily responsible for the hallucinogenic effects of Psilocybe “magic mushrooms”.  Though human cultures have used this entheogen for many centuries, we are only just beginning to understand the physiological mechanism by which it produces its psychedelic effects. This slow scientific progress is a result of harsh international drug policy, but I digress… The psychedelic trip is often described as profoundly mind-expanding, and the brain is popularly presumed to...